It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

The consequences of advancing maternal and paternal age are not only relevant for the risk
of natural and assisted conception, but also for the outcome of pregnancy. Although the …

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …

BACKGROUND DNA damage is a hazard that affects all cells of the body. DNA-damage
repair (DDR) mechanisms are in place to repair damage and restore cellular function, as are …

It is well known that maternal ageing not only causes increased spontaneous abortion and
reduced fertility, but it is also a high genetic disease risk. Although assisted reproductive …

Reproductive aging is associated with ovulatory defects. Age‐related ovarian fibrosis
partially contributes to this phenotype as short‐term treatment with anti‐fibrotic compounds …

Purpose Fertility at advanced age has become increasingly common, but the aging of
parents may adversely affect the maturation of gametes and the development of embryos …

Trophectoderm (TE) biopsy and DNA microarray have become the new technologies for
preimplantation genetic diagnosis in humans. In this study, we comprehensively examined …

Chromosome segregation errors are highly frequent in mammalian female meiosis, and
their incidence gradually increases with maternal age. The fate of aneuploid eggs is …

The cytoskeleton consists of filamentous protein polymers that form organized structures,
contributing to a multitude of cell life aspects. It includes three types of polymers: the actin …