Two years of genomic surveillance in Belgium during the SARS-CoV-2 pandemic to attain country-wide coverage and monitor the introduction and spread of emerging …
An adequate SARS-CoV-2 genomic surveillance strategy has proven to be essential for
countries to obtain a thorough understanding of the variants and lineages being imported …
countries to obtain a thorough understanding of the variants and lineages being imported …
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA. 1 phenotype
Variant of concern (VOC) Omicron-BA. 1 has achieved global predominance in early 2022.
Therefore, surveillance and comprehensive characterization of Omicron-BA. 1 in advanced …
Therefore, surveillance and comprehensive characterization of Omicron-BA. 1 in advanced …
Structural understanding of SARS-CoV-2 virus entry to host cells
K Le, S Kannappan, T Kim, JH Lee, HR Lee… - Frontiers in Molecular …, 2023 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …
coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of …
Impaired immune response drives age-dependent severity of COVID-19
J Beer, S Crotta, A Breithaupt, A Ohnemus… - Journal of Experimental …, 2022 - rupress.org
Severity of COVID-19 shows an extraordinary correlation with increasing age. We generated
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …
a mouse model for severe COVID-19 and show that the age-dependent disease severity is …
Total escape of SARS-CoV-2 from dual monoclonal antibody therapy in an immunocompromised patient
L Jaki, S Weigang, L Kern, S Kramme… - Nature …, 2023 - nature.com
Monoclonal antibodies (mAbs) directed against the spike of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat …
syndrome coronavirus 2 (SARS-CoV-2) are effective therapeutic options to combat …
Impact and mitigation of sampling bias to determine viral spread: Evaluating discrete phylogeography through CTMC modeling and structured coalescent model …
Bayesian phylogeographic inference is a powerful tool in molecular epidemiological studies,
which enables reconstruction of the origin and subsequent geographic spread of pathogens …
which enables reconstruction of the origin and subsequent geographic spread of pathogens …
Dissecting naturally arising amino acid substitutions at position L452 of SARS-CoV-2 spike
TS Tan, M Toyoda, H Ode, G Barabona… - Journal of …, 2022 - Am Soc Microbiol
Mutations at spike protein L452 are recurrently observed in severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC), including omicron …
syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC), including omicron …
Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2
A Taddeo, IB Veiga, C Devisme, R Boss, P Plattet… - NPJ vaccines, 2022 - nature.com
Immunization with vesicular stomatitis virus (VSV)-vectored COVID-19 vaccine candidates
expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly …
expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly …
[HTML][HTML] S: D614G and S: H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness
SARS-CoV-2 variants bearing complex combinations of mutations that confer increased
transmissibility, COVID-19 severity, and immune escape, were first detected after S: D614G …
transmissibility, COVID-19 severity, and immune escape, were first detected after S: D614G …
A bias of Asparagine to Lysine mutations in SARS-CoV-2 outside the receptor binding domain affects protein flexibility
Introduction COVID-19 pandemic has been threatening public health and economic
development worldwide for over two years. Compared with the original SARS-CoV-2 strain …
development worldwide for over two years. Compared with the original SARS-CoV-2 strain …