Cytosolic DNA is an indicator of pathogen invasion or DNA damage. The cytosolic DNA
sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase …

During viral infection, sensing of cytosolic DNA by the cyclic GMP-AMP synthase (cGAS)
activates the adaptor protein STING and triggers an antiviral response. Little is known about …

Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that
underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of …

Virus infection modulates both host immunity and host genomic stability. Poly (ADP-ribose)
polymerase 1 (PARP1) is a key nuclear sensor of DNA damage, which maintains genomic …

Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical
for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor …

Innate immune cells are critical in protective immunity against viral infections, involved in
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …

Summary Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but
some non-human primates exhibit resistance via unknown mechanisms. Innate immune …

Summary cGAS-STING signaling is essential for innate immunity. Its misregulation promotes
cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify …

Herpes simplex virus (HSV) 1 stimulates type I IFN expression through the cGAS–STING–
TBK 1 signaling axis. Macrophages have recently been proposed to be an essential source …

During viral infection, virus-derived cytosolic nucleic acids are recognized by host
intracellular specific sensors. The efficacy of this recognition system is crucial for triggering …