The cyclic GMP-AMP synthase (cGAS), upon cytosolic DNA stimulation, catalyzes the
formation of the second messenger 2′ 3′-cGAMP, which then binds to stimulator of …

Recent work suggests that cholesterol metabolism impacts innate immune responses
against infection. However, the key enzymes or the natural products and mechanisms …

Mammalian cells recognize virus-derived nucleic acids using a defined set of intracellular
sensors including the DNA sensors cyclic GMP–AMP (cGAMP) synthase (cGAS) and …

In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP)
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …

Innate immunity is the first line of host defense against invading pathogens. The detection of
aberrant nucleic acids which represent some conserved PAMPs triggers robust type I IFN …

The host takes use of pattern recognition receptors (PRRs) to defend against pathogen
invasion or cellular damage. Among microorganism-associated molecular patterns detected …

Background The signaling molecule stimulator of IFN genes (STING) was identified as a
crucial regulator of the DNA-sensing cyclic GMP-AMP synthase (cGAS)-STING pathway, and …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays
a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic …

Various intracellular pattern recognition receptors (PRRs) recognize cytosolic pathogen-
associated molecular patterns (PAMPs) and damage-associated molecular patterns …

The innate immune system initiates immune responses by pattern‐recognition receptors
(PRR). Virus‐derived nucleic acids are sensed by the retinoic acid‐inducible gene I (RIG‐I) …