Summary Cyclic GMP-AMP synthase (cGAS) senses cytosolic incoming DNA and
consequently activates stimulator of interferon response cGAMP interactor 1 (STING) to …

Stimulator of interferon genes (STING) is a DNA sensor and an important cytoplasmic
adaptor for other DNA sensors, such as Z-DNA binding protein 1 (DAI), DEAD-box helicase …

Cells express multiple molecules aimed at detecting incoming virus and infection.
Recognition of virus infection leads to the production of cytokines, chemokines and …

The innate immune systems detect pathogens via pattern-recognition receptors including
nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate …

As the first barrier of host defense, innate immunity sets up the parclose to keep out external
microbial or virus attacks. Depending on the type of pathogens, several cytoplasm pattern …

Early detection of infectious nucleic acids released from invading pathogens by the innate
immune system is critical for immune defense. Detection of these nucleic acids by host …

Stimulator of interferons genes (STING) is an adaptor protein that plays a critical role in the
secretion of type I interferons and pro‐inflammatory cytokines in response to cytosolic …

Abstract Cyclic GMP-AMP synthase (cGAS), a key sensor of intracellular DNA, is essential
for eliciting innate immunity against infection, whereas aberrant activation of cGAS by …

Background As an important danger signal, the presence of DNA in cytoplasm triggers
potent immune responses. Cyclic GMP-AMP synthase (cGAS) is a recently characterized …

In higher eukaryotes, sophisticate regulation of genome function requires all chromosomes
to be packed into a single nucleus. Micronucleus (MN), the dissociative nucleus-like …