This study examined the relation between immune response to cytomegalovirus (CMV) and
all-cause and cardiovascular disease (CVD) mortality, and possible mediating mechanisms …

The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …

Aging is accompanied by the development of low‐grade systemic inflammation, termed
'inflammaging', characterized by raised serum C‐reactive protein (CRP) and pro …

Recently, the term" inflammaging" was coined by Franceshci and colleagues to characterize
a widely accepted paradigm that ageing is accompanied by a low-grade chronic up …

Beyond midlife, the immune system shows aging features and its defensive capability
becomes impaired, by a process known as immunosenescence that involves many changes …

Accumulating data are documenting an inverse relationship between immune status,
response to vaccination, health, and longevity, suggesting that the immune system becomes …

PURPOSE: Aging is accompanied by a progressive increase in pro-inflammatory cytokine
status. However, little is known about the development of age-dependent modifications in …

The world's elderly population is expanding rapidly, and we are now faced with the
significant challenge of maintaining or improving physical activity, independence, and …

An age-related decline in immune responses in the elderly results in greater susceptibility to
infection and reduced responses to vaccination. This decline in immune function affects both …

Is immunosenescence an intrinsic ageing process leading to dysregulation of immunity or
an adaptive response of the individual to pathogen exposure? Age-associated differences in …