The human immune system evolved to defend the organism against pathogens, but is
clearly less well able to do so in the elderly, resulting in greater morbidity and mortality due …

The age-associated decline in immune function, referred to as immunosenescence, is well
characterised within the adaptive immune system, and in particular, among T cells …

The inflammatory status of old age can be nurtured from the... : Current Opinion in Clinical
Nutrition & Metabolic Care The inflammatory status of old age can be nurtured from the …

Associations have been reported between plasma Cu and Zn levels and the incidence of the
most important age-related diseases. Previously proposed methods of using plasma Cu/Zn …

Chronic inflammation, a decline in immune responsiveness, and reduced cardiovascular
function are all associated with aging, but the relationships among these phenomena …

Advancing age is characterized by functional and phenotypic alterations in the distribution of
circulating T-cell subsets, some of which are exacerbated by a latent infection with the …

As humans age, their immune systems undergo a process known as immunosenescence.
This global aging of the immune system is associated with increased susceptibility to …

Frailty is a term used as a marker of vulnerability, identifying individuals with a diminished
capacity to respond to external stressors. Those who are frail are at increased risk of death …

SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases
and has established diverse roles in aging, metabolism and disease. Its function is similar to …

In the present NONA immune longitudinal study, we investigate the previously identified
Immune Risk Profile (IRP), defined by an inverted CD4/CD8 ratio and associated with …