Background Precision cancer medicine depends on defining distinct tumour subgroups
using biomarkers that may occur at very modest frequencies. One such subgroup comprises …

Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world.
It is a heterogeneous disease, which can be classified into different subtypes, characterized …

Despite new and more effective cytotoxic chemotherapy, limitations to conventional agents
have been reached in a subset of patients with advanced colorectal cancer (CRC). The …

Background The distinction between right-sided and left-sided colon cancer has recently
received considerable attention due to differences regarding underlying genetic mutations …

Objective Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal
carcinomas, but their biology is incompletely understood. We performed a …

The decision to treat a patient with stage II colon cancer with adjuvant chemotherapy can be
challenging. Although the benefit of treatment is clear in most patients with stage III disease …

Colorectal cancer is a serious health problem, a challenge for research, and a model for
studying the molecular mechanisms involved in its development. According to its incidence …

Inflammatory cells are an essential component of the tumor microenvironment. Neutrophils
have emerged as important players in the orchestration and effector phase of innate and …

Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

Between 8% and 12% of patients with metastatic colorectal cancer (mCRC) harbor a BRAF-
V600E mutation in their tumors, which is associated with a poor response to standard …