Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

Protein ubiquitination has become one of the most extensively studied post-translational
modifications. Originally discovered as a critical element in highly regulated proteolysis …

Emerging evidence suggests that USP39 plays an important role in the development of
hepatocellular carcinoma (HCC). However, the molecular mechanism by which USP39 …

Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

Hepatic stellate cells (HSCs) are activated by inflammatory mediators to secrete extracellular
matrix for collagen deposition, leading to liver fibrosis. Ferroptosis is iron-and lipid …

The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in
various biological processes, especially in regulating a wide range of signaling pathways …

The worldwide SARS-CoV-2 outbreak poses a serious challenge to human societies and
economies. SARS-CoV-2 proteins orchestrate complex pathogenic mechanisms that …

Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including melanoma
differentiation-associated gene 5 (MDA5) and RIG-I, are crucial for host recognition of non …

The innate antiviral response is integral in protecting the host against virus infection. Many
proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin …