Purpose This review provides an overview of the current challenges in oral targeted
antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug …

Computational oncology is a generic term that encompasses any form of computer-based
modelling relating to tumour biology and cancer therapy. Mathematical modelling can be …

Pharmacometric methods have hugely benefited from progress in analytical and computer
sciences during the past decades, and play nowadays a central role in the clinical …

Neonates, infants, and children differ from adults in many aspects, not just in age, weight,
and body composition. Growth, maturation and environmental factors affect drug kinetics …

Quinoxalines are benzopyrazines containing benzene and pyrazine rings fused together. In
the recent past, quinoxalines have attracted Medicinal Chemists considerably for their …

Therapeutic drug monitoring (TDM) aims to optimize treatments by individualizing dosage
regimens based on the measurement of blood concentrations. Dosage individualization to …

The oxazaphosphorines including cyclophosphamide (CPA), ifosfamide (IFO), and
trofosfamide represent an important group of therapeutic agents due to their substantial …

Difficulties in direct measurement of drug concentrations in human tissues have hampered
the understanding of drug accumulation in tumors and normal tissues. We propose a new …

This article summarizes part of a consensus meeting about mycophenolate (MPA)
therapeutic drug monitoring held in Rome under the auspices of The Transplantation …

Learning Objectives After completing this course, the reader will be able to: Describe how
and why BSA-based dosing was implemented into oncology. Discuss if flat-fixed dosing of …