Background Depression, a common psychiatric illness and global public health problem,
remains poorly understood across different life stages, which hampers the development of …

Lewy body dementia (LBD), a class of disorders comprising Parkinson's disease dementia
(PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological …

Personality is influenced by both genetic and environmental factors and is associated with
other psychiatric traits such as anxiety and depression. The “Big Five” personality traits …

Comorbidities are an increasing global health challenge. Accumulating evidence suggests
overlapping genetic architectures underlying comorbid complex human traits and disorders …

Genome-wide association studies (GWAS) of psychiatric disorders (PD) yield numerous loci
with significant signals, but often do not implicate specific genes. Because GWAS risk loci …

Study Design. We used a cohort of subjects diagnosed with SCZ, BPD or MDD, and non-
psychiatrically ill control subjects (n= 15/group), together with our bioinformatic 3-pod …

Background Paroxetine (PX) is a widely used antidepressant with side effects such as
weakness, dizziness, and trouble sleeping. In search of novel compounds with better …

Background: The genome-wide association study (GWAS) is a common tool to identify
genetic variants associated with complex traits, including psychiatric disorders (PDs) …

The brain is comprised of multiple regions performing distinct functions. Within each of these
regions, there are multiple cell types that can affect brain physiology. Finally, within each cell …

Mutations in presenilin-1 (PSEN1) are the most common cause of familial, early-onset
Alzheimer's disease (AD), typically producing cognitive deficits in the fourth decade. A …