The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

The current evidence on the association of leukocyte telomere length (LTL) with age-related
structural and cognitive changes in the brain is mixed. Herein conforming to PRISMA 2020 …

The improvement of life quality and medical advances has resulted in increased life
expectancy. Despite this, health status commonly worsens in the last years of life. Frailty is …

The antiretroviral treatment (ART) developed to control HIV infection led to a revolution in the
prognosis of people living with HIV (PLWH). PLWH underwent from suffering severe disease …

Hippuric acid (HA) is a metabolite resulting from the hepatic glycine conjugation of benzoic
acid (BA) or from the gut bacterial metabolism of phenylalanine. BA is generally produced by …

Precision health, by means of the support of precision medicine and precision nursing, is
able to support clinical decision making in order to tailor optimal health-care decisions …

WHO has defined intrinsic capacity (IC) as the composite of all physical and mental
capacities of an individual covering five subdomains: cognition, locomotion, sensory, vitality …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Aging is closely related to the occurrence of human diseases; however, its exact biological
mechanism is unclear. Advancements in high-throughput technology provide new …

Although the human lifespan has increased in the past century owing to advances in
medicine and lifestyle, the human healthspan has not kept up the same pace, especially in …