Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and
progression, since stromal elements are required to generate the optimal conditions for …

The expeditious advancement in the organ on chip technology provided a phase change to
the conventional in vitro tests used to evaluate absorption, distribution, metabolism …

Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ
biomimetic systems. OOC technology brings numerous advantages in the current landscape …

The study of prostate cancer in vitro relies on established cell lines that lack important
physiological characteristics, such as proper polarization and expression of relevant …

Lack of adequate models significantly hinders advances in prostate cancer treatment, where
resistance to androgen-deprivation therapies and bone metastasis remain as major …

Current biomedical models fail to replicate the complexity of human biology. Consequently,
almost 90% of drug candidates fail during clinical trials after decades of research and …

Given the central role of the androgen receptor (AR) in prostate cancer cell biology, AR-
targeted therapies have been the backbone of prostate cancer treatment for over 50 years …

Tumors are a major cause of death worldwide, and much effort has been made to develop
appropriate anti-tumor therapies. Existing in vitro and in vivo tumor models cannot reflect the …

Microphysiological systems are now widely used to recapitulate physiological and
pathological microenvironments in order to study and understand a variety of cellular …