Abnormalities in the TP53 gene and overexpression of MDM2, a transcriptional target and
negative regulator of p53, are commonly observed in cancers. The MDM2–p53 feedback …

BACKGROUND: The prognostic significance of p53 aberration in hepatocellular carcinoma
(HCC) remains inconclusive. This systematic review and meta-analysis aimed to provide …

Apigenin (Ap) is one of the most important natural flavonoids that has potent anticancer
activity. This study was designed, for the first time, to load Ap into chitosan to improve its …

MicroRNAs (miRNAs) may function as either oncogenes or tumor suppressors in the
malignant progression of different tumor types. MiR-663 was recently reported to be …

Hu antigen R (HuR) is a central RNA‐binding protein regulating cell dedifferentiation,
proliferation, and survival, which are well‐established hallmarks of cancer. HuR is frequently …

Mitochondria are highly dynamic and undergo constant fusion and fission that are essential
for maintaining physiological functions of cells. Recently, we have reported that increased …

Hepatocellular carcinoma (HCC) and liver cirrhosis are associated with high mortality
worldwide. Currently, alpha-fetoprotein (AFP) is used as a standard serum marker for the …

Lipid composition affects membrane function, cell proliferation and cell death and is
changed in cancer tissues. Hepatocellular carcinoma (HCC) is an aggressive cancer and …

Background The purpose of this study of human papillomavirus (HPV), Epstein–Barr virus
(EBV), p21, and p53 in sinonasal inverted papilloma (IP) was to help elucidate its …

The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma
(HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type …