Impact of Plasmodium vivax malaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients
AC Almeida, ABR Elias, MP Marques… - British Journal of …, 2021 - Wiley Online Library
Aims To investigate the impact of Plasmodium vivax malaria and chloroquine‐primaquine
chemotherapy on CYP2D6 and CYP2C19 activity in patients from the Brazilian Amazon …
chemotherapy on CYP2D6 and CYP2C19 activity in patients from the Brazilian Amazon …
Effect of Chronic Hepatitis C on the Activity of the Membrane Transporters P‐gp and OATP1B1/BCRP on Patients With Different Stages of Hepatic Fibrosis
The activity of the membrane transporters organic anion‐transporting polypeptide 1B1
(OATP1B1) & breast cancer resistance protein (BCRP)(rosuvastatin) and P‐glycoprotein (P …
(OATP1B1) & breast cancer resistance protein (BCRP)(rosuvastatin) and P‐glycoprotein (P …
Application of microdosed intravenous omeprazole to determine hepatic CYP2C19 activity
M Mahmoudi, KI Foerster, J Burhenne… - The Journal of …, 2021 - Wiley Online Library
Omeprazole is an established probe drug to assess cytochrome P450 (CYP) 2C19 activity
(phenotyping). Because it has nonlinear pharmacokinetics (PK) after oral administration …
(phenotyping). Because it has nonlinear pharmacokinetics (PK) after oral administration …
Intestinal P‐gp activity is reduced in postmenopausal women under breast cancer therapy
Intestinal P‐glycoprotein (P‐gp) activity plays a crucial role in modulating the oral
bioavailability of its substrates. Fexofenadine has commonly been used as a P‐gp probe …
bioavailability of its substrates. Fexofenadine has commonly been used as a P‐gp probe …
Fexofenadine Plasma Concentrations to Estimate Systemic Exposure in Healthy Adults Using a Limited Sampling Strategy with a Population Pharmacokinetic …
J Piscitelli, M Nikanjam, EV Capparelli… - Therapeutic Drug …, 2023 - journals.lww.com
Background: Fexofenadine is a recommended in vivo probe drug for phenotyping P-
glycoprotein (P-gp) and organic anion transporting polypeptide (OATP) 1B1/3 transporter …
glycoprotein (P-gp) and organic anion transporting polypeptide (OATP) 1B1/3 transporter …
[HTML][HTML] Limitations of fexofenadine limited sampling strategy using plasma concentrations and partial area under the concentration-time curve to estimate transporter …
M Liyanage, CL Blaquera, J Piscitelli… - … Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Objective: Fexofenadine is a probe drug used to phenotype P-glycoprotein (P-gp) and
organic anion transporting polypeptide (OATP) 1B1/3 activities. This study evaluated a …
organic anion transporting polypeptide (OATP) 1B1/3 activities. This study evaluated a …
[图书][B] Quantifying protein expression and activity complements genetics to optimize the use of targeted therapies in precision oncology
CA Sobsey - 2023 - search.proquest.com
The analysis of tumour tissues with modern analytic technologies has shown that most
cancer types are composed of multiple subpopulations with distinct molecular signatures …
cancer types are composed of multiple subpopulations with distinct molecular signatures …
Prediction of the Area under the Curve Using Limited-Point Blood Sampling in a Cocktail Study to Assess Multiple CYP Activities
M Miura, S Tanaka, S Uchida, C Kamiya… - Biological and …, 2021 - jstage.jst.go.jp
A cocktail study is an in vivo evaluation method to assess multiple CYP activities via a single
trial and single administration of a cocktail drug that is a combination of multiple CYP …
trial and single administration of a cocktail drug that is a combination of multiple CYP …
[PDF][PDF] シトクロムP450 活性及び薬物相互作用の評価を目的とした臨床試験法に関する研究
三浦基靖 - 2021 - u-shizuoka-ken.repo.nii.ac.jp
CE Collision energy (コリジョンエネルギー) CL Clearance (クリアランス) CLobse Observed
value of clearance (クリアランスの実測値) CLpred Predictied value of clearance …
value of clearance (クリアランスの実測値) CLpred Predictied value of clearance …