The reproducibility crisis (or replication crisis) in biomedical research is a particularly
existential and under-addressed issue in the field of behavioral neuroscience, where, in …

Simple Summary In the past, there was a strong focus on avoiding or reducing negative
animal welfare in animal experimentation. Recently, the importance of promoting positive …

In humans, infancy and adolescence are associated with major changes in synaptic
functions and ongoing maturation of neural networks, which underlie the major behavioral …

An important factor in reducing variability in mouse test outcomes has been to develop
assays that can be used for continuous automated home cage assessment. Our experience …

Vanishing white matter (VWM) is a fatal leukodystrophy that is caused by mutations in genes
encoding subunits of eukaryotic translation initiation factor 2B (eIF2B). Disease onset and …

De novo heterozygous mutations in STXBP1/Munc18-1 cause early infantile epileptic
encephalopathies (EIEE4, OMIM# 612164) characterized by infantile epilepsy …

Central nervous system disorders such as autism as well as the range of neurodegenerative
diseases such as Huntington's disease are commonly investigated using genetically altered …

Background and aims Automated recording of laboratory animal's home cage behavior is
receiving increasing attention since such non-intruding surveillance will aid in the unbiased …

Cognitive decline is a debilitating aspect of aging and neurodegenerative diseases such as
Alzheimer's disease are closely associated with mitochondrial dysfunction, increased …

Psychedelics, also known as classical hallucinogens, affect processes related to perception,
cognition and sensory processing mostly via the serotonin 5-HT 2A receptor (5-HT 2A R) …