The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …

Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the
generation of induced pluripotent stem cells, have delivered preliminary evidence that …

Background Despite a clear link between aging and cancer, there has been inconclusive
evidence on how biological age (BA) may be associated with cancer incidence. Methods We …

Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue
dysfunction and disease. At the cellular level, ageing is associated with reduced function …

Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

Telomere length (TL) is associated with several aging-related diseases. Here, we present a
DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is …

The pursuit to discover the fundamental biology and mechanisms of aging within the context
of the physical and social environment is critical to designing interventions to prevent and …

Slower epigenetic aging is associated with exposure to green space (greenness); however,
the longitudinal relationship has not been well studied, particularly in minority groups. We …