Epigenetic ageing, ie, age‐associated changes in DNA methylation patterns, is a sensitive
marker of biological ageing, a major determinant of morbidity and functional decline. We …

The identification of genes and interventions that slow or reverse aging is hampered by the
lack of non-invasive metrics that can predict the life expectancy of pre-clinical models. Frailty …

A growing literature suggests that exposure to adverse social conditions may accelerate
biological aging, offering one mechanism through which adversity may increase risk for age …

Major depressive disorder (MDD) is associated with premature mortality and is an
independent risk factor for a broad range of diseases, especially those associated with …

Over the past three decades, considerable effort has been dedicated to quantifying the pace
of ageing yet identifying the most essential metrics of ageing remains challenging due to …

To build health equity for an aging world marked by dramatic disparities in healthy lifespan
between countries, regions and population groups, research at the intersections of biology …

DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an
individual's chronological age and can predict their risk of age-related disease and mortality …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Epigenetic aging clocks have gained significant attention as a tool for predicting age-related
health conditions in clinical and research settings. They have enabled geroscientists to …