Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
Psychological and biological mechanisms linking trauma with cardiovascular disease risk
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and
experiences of psychological trauma have been associated with subsequent CVD onset …
experiences of psychological trauma have been associated with subsequent CVD onset …
Proteomics in aging research: A roadmap to clinical, translational research
R Moaddel, C Ubaida‐Mohien, T Tanaka… - Aging …, 2021 - Wiley Online Library
The identification of plasma proteins that systematically change with age and, independent
of chronological age, predict accelerated decline of health is an expanding area of research …
of chronological age, predict accelerated decline of health is an expanding area of research …
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
Background Individuals of the same chronological age display different rates of biological
ageing. A number of measures of biological age have been proposed which harness age …
ageing. A number of measures of biological age have been proposed which harness age …
[HTML][HTML] DeepMAge: a methylation aging clock developed with deep learning
DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …
since their inception in 2013. Today, a variety of machine learning approaches have been …
DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites
M Krolevets, V Cate, JH Prochaska, A Schulz… - Clinical …, 2023 - Springer
Background Cardiovascular disease (CVD) is the leading cause of death worldwide and
considered one of the most environmentally driven diseases. The role of DNA methylation in …
considered one of the most environmentally driven diseases. The role of DNA methylation in …
The impact of life stress on hallmarks of aging and accelerated senescence: Connections in sickness and in health
CE Lyons, M Razzoli, A Bartolomucci - Neuroscience & Biobehavioral …, 2023 - Elsevier
Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …
Socioeconomic disadvantage and the pace of biological aging in children
METHODS: Saliva DNA methylation and socioeconomic circumstances were measured in
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …
N= 600 children and adolescents aged 8 to 18 years (48% female) participating in the Texas …
A pan-tissue DNA-methylation epigenetic clock based on deep learning
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …
created in recent years, with the vast majority based on regularized linear regression. This …
COVID-19 and crosstalk with the hallmarks of aging
Within the past several decades, the emergence of new viral diseases with severe health
complications and mortality is evidence of an age-dependent, compromised bodily response …
complications and mortality is evidence of an age-dependent, compromised bodily response …