Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study

F Sánchez-Cabo, V Fuster, JC Silla-Castro… - European heart …, 2023 - academic.oup.com
Aims Epigenetic age is emerging as a personalized and accurate predictor of biological age.
The aim of this article is to assess the association of subclinical atherosclerosis with …

Integrating DNA methylation measures of biological aging into social determinants of health research

L Raffington, DW Belsky - Current Environmental Health Reports, 2022 - Springer
Abstract Purpose of Review Acceleration of biological processes of aging is hypothesized to
drive excess morbidity and mortality in socially disadvantaged populations. DNA methylation …

[HTML][HTML] Development of the VISAGE enhanced tool and statistical models for epigenetic age estimation in blood, buccal cells and bones

A Woźniak, A Heidegger, D Piniewska-Róg… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
DNA methylation is known as a biomarker for age with applications in forensics. Here we
describe the VISAGE (VISible Attributes through GEnomics) Consortium's enhanced tool for …

Consensus paper: cerebellum and ageing

A Arleo, M Bareš, JA Bernard, HR Bogoian… - The Cerebellum, 2024 - Springer
Given the key roles of the cerebellum in motor, cognitive, and affective operations and given
the decline of brain functions with aging, cerebellar circuitry is attracting the attention of the …

[HTML][HTML] Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: evidence from mixture approaches

W Shi, X Gao, Y Cao, Y Chen, Q Cui, F Deng… - Environment …, 2022 - Elsevier
Background Air pollution is associated with accelerated biological ages determined by DNA
methylation (DNAm) patterns, imposing further risks of age-related adverse effects …

How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span

AM Galow, S Peleg - Cells, 2022 - mdpi.com
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective

NA Rivero-Segura, OY Bello-Chavolla… - Ageing research …, 2020 - Elsevier
The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

Epigenetic age and the risk of incident atrial fibrillation

JD Roberts, E Vittinghoff, AT Lu, A Alonso, B Wang… - Circulation, 2021 - Am Heart Assoc
Background: The most prominent risk factor for atrial fibrillation (AF) is chronological age;
however, underlying mechanisms are unexplained. Algorithms using epigenetic …

Racial and ethnic residential segregation and monocyte DNA methylation age acceleration

MT Hicken, J Dou, KN Kershaw, Y Liu, A Hajat… - JAMA network …, 2023 - jamanetwork.com
Importance Neighborhood segregation and poverty may be important drivers of health
inequities. Epigenomic factors, including DNA methylation clocks that may mark underlying …

Longitudinal phenotypic aging metrics in the Baltimore Longitudinal Study of Aging

PL Kuo, JA Schrack, ME Levine, MD Shardell… - Nature aging, 2022 - nature.com
To define metrics of phenotypic aging, it is essential to identify biological and environmental
factors that influence the pace of aging. Previous attempts to develop aging metrics were …