Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases

S Bonnet, O Boucherat, R Paulin… - … of Physiology-Cell …, 2020 - journals.physiology.org
Although a majority of the mammalian genome is transcribed to RNA, mounting evidence
indicates that only a minor proportion of these transcriptional products are actually translated …

Clinical utility of microRNAs in exhaled breath condensate as biomarkers for lung cancer

C Pérez-Sánchez, N Barbarroja, LC Pantaleão… - Journal of personalized …, 2021 - mdpi.com
This study represents a novel proof of concept of the clinical utility of miRNAs from exhaled
breath condensate (EBC) as biomarkers of lung cancer (LC). Genome-wide miRNA profiling …

Small RNA sequencing and bioinformatics analysis of RAW264. 7-derived exosomes after Mycobacterium Bovis Bacillus Calmette-Guérin infection

X Zhan, W Yuan, Y Zhou, R Ma, Z Ge - BMC genomics, 2022 - Springer
Background The mechanisms through which Mycobacterium tuberculosis evades immune
surveillance during tuberculosis (TB) infection remain complex. Previous studies have found …

Diagnostic and therapeutic applications of exosomes in cancer with a special focus on head and neck squamous cell carcinoma (HNSCC)

E Ebnoether, L Muller - International journal of molecular sciences, 2020 - mdpi.com
Exosomes are nanovesicles part of a recently described intercellular communication system.
Their properties seem promising as a biomarker in cancer research, where more sensitive …

MicroRNA‑199a‑5p functions as a tumor suppressor in oral squamous cell carcinoma via targeting the IKKβ/NF‑κB signaling pathway

D Wei, B Shen, W Wang, Y Zhou… - International …, 2019 - spandidos-publications.com
MicroRNAs (miRNAs) have been shown to have a significant role in the progression of
several types of cancer, including oral squamous cell carcinoma (OSCC). However, the …

Extracellular vesicles' role in the pathophysiology and as biomarkers in cystic fibrosis and COPD

S Di Gioia, V Daniello, M Conese - International Journal of Molecular …, 2022 - mdpi.com
In keeping with the extraordinary interest and advancement of extracellular vesicles (EVs) in
pathogenesis and diagnosis fields, we herein present an update to the knowledge about …

Exosomes in severe asthma: update in their roles and potential in therapy

E Mortaz, SD Alipoor, M Varahram… - BioMed research …, 2018 - Wiley Online Library
Exosomes are nanosized vesicles and have recently been recognized as important players
in cell‐to‐cell communication. Exosomes contain different mediators such as proteins …

Radiation-induced pulmonary epithelial-mesenchymal transition: a review on targeting molecular pathways and mediators

SS Nagaraja, D Nagarajan - Current Drug Targets, 2018 - ingentaconnect.com
Background: Radiotherapy is the most widely used treatment method for average and
advanced lung cancer patients. Moreover, the clinical toxicities caused by radiotherapy are …

The effects of the miR-21/SMAD7/TGF-β pathway on Th17 cell differentiation in COPD

S He, S Sun, J Lu, L Chen, X Mei, L Li, Z Zeng… - Scientific Reports, 2021 - nature.com
Chronic obstructive pulmonary disease (COPD) is a complex disease with multiple
etiologies, while smoking is the most established one. The present study investigated the …

A graphene-based fluorescent nanoprobe for simultaneous imaging of dual miRNAs in living cells

X Xiong, W Dang, R Luo, Y Long, C Tong, L Yuan… - Talanta, 2021 - Elsevier
MicroRNAs (miRNAs) are regarded as important biomarkers for disease diagnostics and
therapeutics due to their significant regulatory roles in physiologic and pathologic …