Biodistribution of exosomes and engineering strategies for targeted delivery of therapeutic exosomes

H Choi, Y Choi, HY Yim, A Mirzaaghasi, JK Yoo… - Tissue engineering and …, 2021 - Springer
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules
for intercellular communication. Due to their therapeutic potential, exosomes have been …

Recent progresses in exosome-based systems for targeted drug delivery to the brain

S Bashyal, C Thapa, S Lee - Journal of Controlled Release, 2022 - Elsevier
Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

Intranasal administration of self-oriented nanocarriers based on therapeutic exosomes for synergistic treatment of Parkinson's disease

H Peng, Y Li, W Ji, R Zhao, Z Lu, J Shen, Y Wu… - ACS …, 2022 - ACS Publications
The treatment of Parkinson's disease (PD) has been hindered by the complex pathologies
and multiple membrane barriers during drug delivery. Although exosomes derived from …

Microneedle patch loaded with exosomes containing microRNA‐29b prevents cardiac fibrosis after myocardial infarction

J Yuan, H Yang, C Liu, L Shao, H Zhang… - Advanced …, 2023 - Wiley Online Library
Myocardial infarction (MI) is a cardiovascular disease that poses a serious threat to human
health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a …

Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

A Hazrati, S Soudi, K Malekpour, M Mahmoudi… - Biomarker …, 2022 - Springer
Exosomes, ranging in size from 30 to 150 nm as identified initially via electron microscopy in
1946, are one of the extracellular vesicles (EVs) produced by many cells and have been the …

Exosomes as naturally occurring vehicles for delivery of biopharmaceuticals: insights from drug delivery to clinical perspectives

A Butreddy, N Kommineni, N Dudhipala - Nanomaterials, 2021 - mdpi.com
Exosomes as nanosized vesicles are emerging as drug delivery systems for therapeutics
owing to their natural origin, their ability to mediate intercellular communication, and their …

[HTML][HTML] Engineering strategies and optimized delivery of exosomes for theranostic application in nerve tissue

Q Li, X Fu, Y Kou, N Han - Theranostics, 2023 - ncbi.nlm.nih.gov
Severe injuries or diseases affecting the peripheral and central nervous systems can result
in impaired organ function and permanent paralysis. Conventional interventions, such as …

Exosomes: another intercellular lipometabolic communication mediators in digestive system neoplasms?

S Li, R Dong, Z Kang, H Li, X Wu, T Li - Cytokine & growth factor reviews, 2023 - Elsevier
Neoplasms are one of the most concerned public health problems worldwide. Digestive
system neoplasms, with a high morbidity and mortality, is one of the most common malignant …

Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Q Liu, D Li, X Pan, Y Liang - Journal of nanobiotechnology, 2023 - Springer
Abstract Extracellular vesicles (EVs) are 30–150 nm membrane-bound vesicles naturally
secreted by cells and play important roles in intercellular communication by delivering …

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors

E Ghasempour, S Hesami, E Movahed… - Stem Cell Research & …, 2022 - Springer
Brain tumors are one of the most mortal cancers, leading to many deaths among kids and
adults. Surgery, chemotherapy, and radiotherapy are available options for brain tumor …