Neurodegenerative diseases (NDs) result from progressive deterioration of selectively
susceptible neuron populations in different central nervous system (CNS) regions. NDs are …

Abstract Sirtuin-3 (SIRT3) is a NAD+-dependent protein deacetylase that is located in
mitochondria, regulating mitochondrial proteins and maintaining cellular antioxidant status …

Parkinson's disease involves multiple neurotransmitter systems beyond the classical
dopaminergic circuit, but their influence on structural and functional alterations is not well …

Direct reprogramming based on genetic factors resembles a promising strategy to replace
lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a …

The fight against neurodegenerative diseases, Alzheimer disease and Parkinson's disease
(PD), is a challenge of the 21st century. The low efficacy of treating patients is due to the late …

MicroRNAs (miRNAs) are small double-stranded RNAs that exert a fine-tuning sequence-
specific regulation of cell transcriptome. While one unique miRNA regulates hundreds of …

Parkinson's disease (PD) is a common neurodegenerative disease characterized by the
degeneration of nigrostriatal dopaminergic (DA) neurons. Our previous studies have …

Neurodegenerative diseases are devastating and incurable disorders characterized by
neuronal dysfunction. The major focus of experimental and clinical studies are conducted on …

Abstract Resveratrol (RES), a non-flavonoid polyphenol extracted from a wide variety of
plants, exhibits neuroprotective activities against Parkinson's disease (PD). However …

Stem cells are characterized by their self-renewal and multipotency and have great potential
in the therapy of various disorders. However, the blood–brain barrier (BBB) limits the …