Targeting mitochondria as a therapeutic approach for Parkinson's disease

M Abrishamdar, MS Jalali, Y Farbood - Cellular and molecular …, 2023 - Springer
Neurodegeneration is among the most critical challenges that involve modern societies and
annually influences millions of patients worldwide. While the pathophysiology of Parkinson's …

The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson's disease

Z Chen, M Rasheed, Y Deng - Brain Pathology, 2022 - Wiley Online Library
Mitochondrial dysfunction is one of the crucial factors involved in PD's pathogenicity, which
emerges from a combination of genetic and environmental factors. These factors cause …

BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through …

Z Jiang, J Wang, G Sun, M Feng - Molecular and Cellular Neuroscience, 2022 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease still without any cure. Brain-
derived neurotrophic factor (BDNF) has shown therapeutic potential in PD, which is limited …

Involvement of aberrant regulation of epigenetic mechanisms in the pathogenesis of Parkinson's disease and epigenetic‐based therapies

PG Renani, F Taheri, D Rostami… - Journal of cellular …, 2019 - Wiley Online Library
Parkinson's disease (PD) is known as a progressive neurodegenerative disorder associated
with the reduction of dopamine‐secreting neurons and the formation of Lewy bodies in the …

LncRNAs as putative biomarkers and therapeutic targets for Parkinson's disease

E Taghizadeh, SM Gheibihayat, F Taheri… - Neurological …, 2021 - Springer
Parkinson's disease (PD) is known as one of the most common degenerative disorders
related to the damage of the central nervous system (CNS). This brain disorder is also …

[HTML][HTML] Repositioning and development of new treatments for neurodegenerative diseases: Focus on neuroinflammation

BD Arbo, LE Schimith, MG Dos Santos… - European Journal of …, 2022 - Elsevier
Neurodegenerative disorders, such as Alzheimer's and Parkinson's disease, are
characterized by the progressive loss of neuronal cells, resulting in different clinical …

[HTML][HTML] Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro

R Zeng, Q Zhou, W Zhang, X Fu, Q Wu, Y Lu, J Shi… - Toxicology reports, 2019 - Elsevier
Rotenone (ROT) is an environmental neurotoxin which has been demonstrated to cause
characteristic loss of dopamine (DA) neurons in Parkinson's disease (PD). Icariin (ICA) is a …

A recent update on drugs and alternative approaches for parkinsonism

S Kispotta, D Das, SK Prusty - Neuropeptides, 2024 - Elsevier
Parkinson's disease, often known as PD, is a more common age-related neurological
disorder that affects a huge number of older adults worldwide. Parkinson's disease is …

Evaluation of the neuroprotective potential of caffeic acid phenethyl ester in a cellular model of Parkinson's disease

D Turan, H Abdik, F Sahin, EA Abdik - European journal of pharmacology, 2020 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, and
oxidative stress and mitochondrial dysfunction play a major role in the pathogenesis of PD …

Research advances on L-DOPA-induced dyskinesia: from animal models to human disease

X Chen, Y Wang, H Wu, C Cheng, W Le - Neurological Sciences, 2020 - Springer
Abstract L-3, 4-dihydroxyphenylalanine (L-DOPA) was introduced about half a century ago
and is still the most effective medicine for the treatment of Parkinson's disease (PD) …