In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism
and is considered one of the most significant pathogens that produce chronic colonization …

Rationale: The promise of newborn screening (NBS) for cystic fibrosis (CF) has not been
fully realized, and the extent of improvement in respiratory outcomes is unclear. We …

Rationale: Better understanding of evolution of lung function in infants with cystic fibrosis
(CF) and its association with pulmonary inflammation and infection is crucial in informing …

OBJECTIVES: To determine the prevalence of bronchiectasis in young children with cystic
fibrosis (CF) diagnosed after newborn screening (NBS) and the relationship of …

BACKGROUND: Staphylococcus aureus (S. aureus) is one of the earliest bacteria detected
in infants and children with cystic fibrosis (CF). The rise of methicillin resistant S. aureus …

Culture of bronchoalveolar lavage fluid (BALF) is the gold standard for detection of
pathogens in the lower airways in cystic fibrosis (CF). However, current culture results do not …

Rationale: Pulmonary inflammation, infection, and structural lung disease occur early in life
in children with cystic fibrosis. Objectives: We hypothesized that the presence of these …

Chronic inflammation of the lung, as a consequence of persistent bacterial infections by
several opportunistic pathogens represents the main cause of mortality and morbidity in …

Rationale: Classical interpretation of cystic fibrosis (CF) lung disease pathogenesis
suggests that infection initiates disease progression, leading to an exuberant inflammatory …