The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

New Findings What is the topic of this review? The manuscript collectively combines the
experimental observations from> 100 publications focusing on the regulation of cerebral …

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

Senescence is a leading cause of mortality, disability, and non‐communicable chronic
diseases in older adults. Mounting evidence indicates that the presence of cardiovascular …

Arterial blood pressure is the driving force for organ perfusion. Although hypotension is
common in acute care, there is a lack of accepted criteria for its definition. Most practitioners …

Regulation of the cerebral circulation relies on the complex interplay between
cardiovascular, respiratory, and neural physiology. In health, these physiologic systems act …

Cognitive impairment is common in patients with cardiovascular disease. One in 3 patients
presenting at cardiology clinics have some degree of cognitive impairment, depending on …

Rationale: Secondary brain hypoxia portends significant mortality in ischemic brain
diseases; yet, our understanding of hypoxic ischemic brain injury (HIBI) pathophysiology in …

Abstract Background and Purpose Cognitive decline is an important contributor to disability
in patients with chronic heart failure, affecting 25%–50% of patients. The aim of this review is …

Diseases affecting the brain contribute to a substantial proportion of morbidity and mortality
in the general population. Conditions such as stroke, dementia and cognitive impairment …