Pathophysiology to advanced intra-articular drug delivery strategies: unravelling rheumatoid arthritis

H Singh, A Dan, MK Kumawat, V Pawar, DS Chauhan… - Biomaterials, 2023 - Elsevier
Rheumatoid arthritis (RA) is one of the most prevalent life-long autoimmune diseases with
an unknown genesis. It primarily causes chronic inflammation, pain, and synovial joint …

Recent developments in nanomaterials for upgrading treatment of orthopedics diseases

J Shang, C Zhou, C Jiang, X Huang, Z Liu… - … in Bioengineering and …, 2023 - frontiersin.org
Nanotechnology has changed science in the last three decades. Recent applications of
nanotechnology in the disciplines of medicine and biology have enhanced medical …

[HTML][HTML] Injectable hyperbranched PEG crosslinked hyaluronan hydrogel microparticles containing mir-99a-3p modified subcutaneous ADSCs-derived exosomes was …

Z Yin, C Qin, S Pan, C Shi, G Wu, Y Feng, J Zhang… - Materials Today Bio, 2023 - Elsevier
Exosomes (Exos) secreted by adipose-derived stem cells (ADSCs) have shown potential in
alleviating osteoarthritis (OA). Previous studies indicated that infrapatellar fat pad (IPFP) …

Drug-embedded nanovesicles assembled from peptide-decorated hyaluronic acid for rheumatoid arthritis synergistic therapy

Q Hu, F Zhang, Y Wei, J Liu, Y Nie, J Xie… - …, 2023 - ACS Publications
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes
endless pain and poor quality of life in patients. Usage of a lubricant combined with anti …

[HTML][HTML] Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy

M Duan, S Xia, Y Liu, X Pu, Y Chen, Y Zhou… - Materials Today Bio, 2023 - Elsevier
Articular cartilage, composed of collagen type II as a major extracellular matrix and
chondrocyte as a unique cell type, is a specialized connective tissue without blood vessels …

[HTML][HTML] Nanocrystal-chitosan particles for intra-articular delivery of disease-modifying osteoarthritis drugs

L Morici, P Gonzalez-Fernandez, S Jenni… - International Journal of …, 2024 - Elsevier
Osteoarthritis is the most common chronic joint disease and a major health care concern
due to the lack of efficient treatments. This is mainly related to the local and degenerative …

Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy

S Meng, Z Song, Z Tang, X Yang, Y Xiao, H Guo… - Biomaterials …, 2023 - pubs.rsc.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes progressive joint
destruction, leading to impaired life quality, disability, and even premature mortality …

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

S Cheng, KH Wang, L Zhou, ZJ Sun… - Advanced Healthcare …, 2024 - Wiley Online Library
Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive
pulmonary disease, and celiac disease, disrupt the delicate balance between bone …

Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

M Fatima, WH Almalki, T Khan, A Sahebkar… - Advanced …, 2024 - Wiley Online Library
The quest for effective and reliable methods of delivering medications, with the aim of
improving delivery of therapeutic agent to the intended location, has presented a demanding …

Therapeutics of the future: Navigating the pitfalls of extracellular vesicles research from an osteoarthritis perspective

A Karoichan, S Boucenna… - Journal of Extracellular …, 2024 - Wiley Online Library
Extracellular vesicles have gained wide momentum as potential therapeutics for
osteoarthritis, a highly prevalent chronic disease that still lacks an approved treatment. The …