Favipiravir, an anti-influenza drug against life-threatening RNA virus infections

K Shiraki, T Daikoku - Pharmacology & therapeutics, 2020 - Elsevier
Favipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza
drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a …

Favipiravir as a potential countermeasure against neglected and emerging RNA viruses

L Delang, R Abdelnabi, J Neyts - Antiviral research, 2018 - Elsevier
Favipiravir, also known as T-705, is an antiviral drug that has been approved in 2014 in
Japan to treat pandemic influenza virus infections. The drug is converted intracellularly into …

[HTML][HTML] STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

R Boudewijns, HJ Thibaut, SJF Kaptein, R Li… - Nature …, 2020 - nature.com
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of
deaths. In search for key targets of effective therapeutics, robust animal models mimicking …

[HTML][HTML] Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy

MA Casel, SJ Park, YK Choi - Experimental & molecular medicine, 2021 - nature.com
An emerging infectious disease first identified in central China in 2009, severe fever with
thrombocytopenia syndrome (SFTS) was found to be caused by a novel phlebovirus. Since …

[HTML][HTML] Clinical update of severe fever with thrombocytopenia syndrome

JW Seo, D Kim, N Yun, DM Kim - Viruses, 2021 - mdpi.com
Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile illness
characterized by fever, leukopenia, thrombocytopenia, and gastrointestinal symptoms such …

[HTML][HTML] Favipiravir (T-705) protects against Nipah virus infection in the hamster model

BE Dawes, B Kalveram, T Ikegami, T Juelich… - Scientific reports, 2018 - nature.com
Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus
Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality …

[HTML][HTML] Heartland virus epidemiology, vector association, and disease potential

AC Brault, HM Savage, NK Duggal, RJ Eisen… - Viruses, 2018 - mdpi.com
First identified in two Missouri farmers exhibiting low white-blood-cell and platelet counts in
2009, Heartland virus (HRTV) is genetically closely related to severe fever with …

[HTML][HTML] Syrian hamster as an animal model for the study on infectious diseases

J Miao, LS Chard, Z Wang, Y Wang - Frontiers in immunology, 2019 - frontiersin.org
Infectious diseases still remain one of the biggest challenges for human health. In order to
gain a better understanding of the pathogenesis of infectious diseases and develop effective …

[HTML][HTML] A multicenter non-randomized, uncontrolled single arm trial for evaluation of the efficacy and the safety of the treatment with favipiravir for patients with severe …

K Suemori, M Saijo, A Yamanaka… - PLoS Neglected …, 2021 - journals.plos.org
Severe fever with thrombocytopenia syndrome (SFTS) is a bunyavirus infection with high
mortality. Favipiravir has shown effectiveness in preventing and treating SFTS virus (SFTSV) …

Pathophysiology of severe fever with thrombocytopenia syndrome and development of specific antiviral therapy

M Saijo - Journal of infection and chemotherapy, 2018 - Elsevier
Severe fever with thrombocytopenia syndrome (SFTS) caused by SFTS virus (SFTSV), a
novel phlebovirus, was reported to be endemic to central and northeastern PR China and …