Nonstructural protein NSs hampers cellular antiviral response through LSm14A during severe fever with thrombocytopenia syndrome virus infection

L Zhang, Y Fu, R Zhang, Y Guan, N Jiang… - The Journal of …, 2021 - journals.aai.org
The nonstructural protein (NSs) of severe fever with thrombocytopenia syndrome virus
(SFTSV) plays multiple functions in the virus life cycle. Proteomic screening for host proteins …

Structural and functional similarities in bunyaviruses: Perspectives for pan‐bunya antivirals

S Ter Horst, N Conceição‐Neto, J Neyts… - Reviews in Medical …, 2019 - Wiley Online Library
The order of Bunyavirales includes numerous (re) emerging viruses that collectively have a
major impact on human and animal health worldwide. There are no vaccines for human use …

The NSs protein of severe fever with thrombocytopenia syndrome virus differentially inhibits the type 1 interferon response among animal species

R Yoshikawa, M Kawakami, J Yasuda - Journal of Biological Chemistry, 2023 - ASBMB
Severe fever with thrombocytopenia syndrome virus (SFTSV), which has been reported in
China, Korea, Japan, Vietnam, and Taiwan, is a causative agent of severe fever …

Severe fever with thrombocytopenia syndrome (SFTS) treated with a novel antiviral medication, favipiravir (T-705)

R Song, Z Chen, W Li - Infection, 2020 - Springer
Background Severe fever and thrombocytopenia syndrome (SFTS) is an acute illness with a
high mortality (16.2–29.1%). Unfortunately, there is no specific cure or vaccine for SFTS …

[HTML][HTML] Heartland virus infection in hamsters deficient in type I interferon signaling: Protracted disease course ameliorated by favipiravir

JB Westover, JD Rigas, AJ Van Wettere, R Li… - Virology, 2017 - Elsevier
Heartland virus (HRTV) is an emerging tick-borne virus (Bunyaviridae, Phlebovirus) that has
caused sporadic cases of human disease in several central and mid-eastern states of …

Characterization of an N-terminal non-core domain of RAG1 gene disrupted Syrian hamster model generated by CRISPR Cas9

J Miao, B Ying, R Li, AE Tollefson, JF Spencer… - Viruses, 2018 - mdpi.com
The accumulating evidence demonstrates that Syrian hamsters have advantages as models
for various diseases. To develop a Syrian hamster (Mesocricetus auratus) model of human …

Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors

M Baba, M Toyama, N Sakakibara… - Antiviral Chemistry …, 2017 - journals.sagepub.com
Aims Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne
infectious disease. SFTS is epidemic in Asia, and its fatality rate is around 30% in Japan …

Vascular leak and hypercytokinemia associated with severe fever with thrombocytopenia syndrome virus infection in mice

JB Westover, BT Hickerson, AJ Van Wettere, BL Hurst… - Pathogens, 2019 - mdpi.com
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic
fever (VHF) endemic to China, South Korea, Japan, and Vietnam. Here we characterize the …

M segment-based minigenome system of severe fever with thrombocytopenia syndrome virus as a tool for antiviral drug screening

H Yamada, S Taniguchi, M Shimojima, L Tan… - Viruses, 2021 - mdpi.com
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne
bunyavirus that causes severe disease in humans with case fatality rates of approximately …

Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies

BB Gowen, BT Hickerson - Journal of Microbiology, 2017 - Springer
A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a
severe febrile illness which can progress to hypovolemic shock and multi-organ failure and …