Noninvasive early identification of therapeutic benefit from immune checkpoint inhibition

BY Nabet, MS Esfahani, EJ Moding, EG Hamilton… - Cell, 2020 - cell.com
Although treatment of non-small cell lung cancer (NSCLC) with immune checkpoint
inhibitors (ICIs) can produce remarkably durable responses, most patients develop early …

[HTML][HTML] Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas

BJ Sworder, DM Kurtz, SK Alig, MJ Frank, N Shukla… - Cancer Cell, 2023 - cell.com
Most relapsed/refractory large B cell lymphoma (r/rLBCL) patients receiving anti-CD19
chimeric antigen receptor (CAR19) T cells relapse. To characterize determinants of …

Circulating cell-free DNA for cancer early detection

Q Gao, Q Zeng, Z Wang, C Li, Y Xu, P Cui, X Zhu, H Lu… - The Innovation, 2022 - cell.com
Effective screening modalities are currently available for only a small subset of cancers, and
they generally have suboptimal performance with complicated procedures. Therefore, there …

Trends in the approval of cancer therapies by the FDA in the twenty-first century

EC Scott, AC Baines, Y Gong, R Moore Jr… - Nature Reviews Drug …, 2023 - nature.com
The cancer treatment landscape has changed dramatically since the turn of the century,
resulting in substantial improvements in outcomes for patients. This Review summarizes …

The origin of highly elevated cell-free DNA in healthy individuals and patients with pancreatic, colorectal, lung, or ovarian cancer

AK Mattox, C Douville, Y Wang, M Popoli, J Ptak… - Cancer discovery, 2023 - AACR
Cell-free DNA (cfDNA) concentrations from patients with cancer are often elevated
compared with those of healthy controls, but the sources of this extra cfDNA have never …

Circulating tumor DNA minimal residual disease detection of non–small-cell lung cancer treated with curative intent

B Pellini, AA Chaudhuri - Journal of Clinical Oncology, 2022 - ascopubs.org
Circulating tumor DNA (ctDNA) minimal residual disease (MRD) is a powerful biomarker
with the potential to improve survival outcomes for non–small-cell lung cancer (NSCLC) …

Evolutionary characterization of lung adenocarcinoma morphology in TRACERx

T Karasaki, DA Moore, S Veeriah… - Nature medicine, 2023 - nature.com
Lung adenocarcinomas (LUADs) display a broad histological spectrum from low-grade
lepidic tumors through to mid-grade acinar and papillary and high-grade solid, cribriform …

[HTML][HTML] Early lung cancer diagnostic biomarker discovery by machine learning methods

Y Xie, WY Meng, RZ Li, YW Wang, X Qian, C Chan… - Translational …, 2021 - Elsevier
Early diagnosis has been proved to improve survival rate of lung cancer patients. The
availability of blood-based screening could increase early lung cancer patient uptake. Our …

Machine learning methods for cancer classification using gene expression data: A review

F Alharbi, A Vakanski - Bioengineering, 2023 - mdpi.com
Cancer is a term that denotes a group of diseases caused by the abnormal growth of cells
that can spread in different parts of the body. According to the World Health Organization …

Bridging biological cfDNA features and machine learning approaches

T Moser, S Kühberger, I Lazzeri, G Vlachos, E Heitzer - Trends in Genetics, 2023 - cell.com
Liquid biopsies (LBs), particularly using circulating tumor DNA (ctDNA), are expected to
revolutionize precision oncology and blood-based cancer screening. Recent technological …