Conspectus Multivalent interactions are common in biological systems and are also widely
deployed for targeting applications in biomedicine. A unique feature of multivalent binding is …

Carbohydrates have long been known to mediate intracellular interactions, whether within
one organism or between different organisms. Sialic acids (Sias) are carbohydrates that …

Moieties that compete with multivalent interactions or act as cofactors are common in living
systems, but their effect on multivalent binding remains poorly understood. We derive a …

The main localization of nucleolin is the nucleolus, but this protein is present in multiple
subcellular sites, and it is unconventionally secreted. On the cell surface, nucleolin acts as a …

Understanding how influenza viruses traverse the mucus and recognize host cells is critical
for evaluating their zoonotic potential, and for prevention and treatment of the disease. The …

Numerous key biological processes rely on the concept of multivalency, where ligands
achieve stable binding only upon engaging multiple receptors. These processes, like viral …

Biosensors and other biological platform technologies require the functionalization of their
surface with receptors to enhance affinity and selectivity. Control over the functionalization …

The influenza A virus (IAV) is a ubiquitous and continuously evolving respiratory pathogen.
The intranasal vaccination mimicking natural infections is an attractive strategy for …

The modification of surfaces with multiple ligands allows the formation of platforms for the
study of multivalency in diverse processes. Herein we use this approach for the …

An affinity chromatography filler of CNBr-activated Sepharose 4B-immobilized ACE was
used to purify ACE-inhibitory peptides from Takifugu flavidus protein hydrolysate (< 1 kDa) …