Chalcone derivatives: role in anticancer therapy

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

Pharmacotherapeutics applications and chemistry of chalcone derivatives

JS Dhaliwal, S Moshawih, KW Goh, MJ Loy… - Molecules, 2022 - mdpi.com
Chalcones have been well examined in the extant literature and demonstrated antibacterial,
antifungal, anti-inflammatory, and anticancer properties. A detailed evaluation of the …

Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease

P Thapa, SP Upadhyay, WZ Suo, V Singh, P Gurung… - Bioorganic …, 2021 - Elsevier
Abstract Chalcone [(E)-1, 3-diphenyl-2-propene-1-one], a small molecule with α, β
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …

Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines

H ur Rashid, MAU Martines, AP Duarte, J Jorge… - RSC …, 2021 - pubs.rsc.org
Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms at
positions 1 and 3 of the six-membered ring. Numerous natural and synthetic pyrimidines are …

[HTML][HTML] Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects

R Pereira, AMS Silva, D Ribeiro, VLM Silva… - European Journal of …, 2023 - Elsevier
Chalcones are bioactive molecules of natural and synthetic sources, whose
physicochemical properties, reactivity, and biological activities are well-known among the …

Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor κb activities

H ur Rashid, Y Xu, N Ahmad, Y Muhammad… - Bioorganic Chemistry, 2019 - Elsevier
Abstract Chalcones (1, 3-Diphenyl-2-propen-1-one) consist of a three carbon α, β-
unsaturated carbonyl system and act as precursors for the biosynthesis of flavonoids in …

Antimicrobial, antioxidant, and anticancer activities of some novel isoxazole ring containing chalcone and dihydropyrazole derivatives

A Shaik, RR Bhandare, K Palleapati, S Nissankararao… - Molecules, 2020 - mdpi.com
Our previous work identified isoxazole-based chalcones and their dihydropyrazole
derivatives as two important five-membered heterocycles having antitubercular activity …

Synthesize, structural inspection, stoichiometry in solution and DFT calculation of some novel mixed ligand complexes: DNA binding, biomedical applications and …

AM Abu-Dief, T El‐Dabea, RM El-Khatib… - Journal of Molecular …, 2024 - Elsevier
Mixed ligand chelates of Pd (II), Cu (II), VO (II), and Ag (I) with (BIP= 4, 6-dimethyl-N-
(octahydro-2H-benzimidazol-2-ylidene) pyrimidin-2-amine) as a main ligand and (Phen= 1 …

A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization

O Ebenezer, M Shapi, JA Tuszynski - International Journal of Molecular …, 2022 - mdpi.com
Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …