X Li, Y Song - European Journal of Medicinal Chemistry, 2023 - Elsevier
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003 infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug development. In this study, we present an antiviral screening strategy involving a novel in …
AC Ferreira, VC Soares… - Cell death …, 2021 - nature.com
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients …
LB Brown, MA Spinelli, M Gandhi - Current Opinion in HIV and …, 2021 - journals.lww.com
Conclusion COVID-19 is threatening gains against the HIV epidemic, including the US Ending the HIV Epidemic goals. The ongoing collision of these two global pandemics will …
K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
The development of effective antiviral therapy for COVID-19 is critical for those awaiting vaccination, as well as for those who do not respond robustly to vaccination. This review …
S Hattori, N Higashi-Kuwata, H Hayashi, SR Allu… - Nature …, 2021 - nature.com
Except remdesivir, no specific antivirals for SARS-CoV-2 infection are currently available. Here, we characterize two small-molecule-compounds, named GRL-1720 and 5h …
Viruses are obligate intracellular parasites that make use of the host metabolic machineries to meet their biosynthetic needs. Thus, identifying the host pathways essential for the virus …
Z Li, X Li, YY Huang, Y Wu, R Liu… - Proceedings of the …, 2020 - National Acad Sciences
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global crisis. There is no therapeutic treatment specific for …
The uncontrolled spread of the COVID-19 pandemic caused by the new coronavirus SARS- CoV-2 during 2020–2021 is one of the most devastating events in the history, with …