The ability to experience pleasurable sexual activity is important for human health.
Receptive anal intercourse (RAI) is a common, though frequently stigmatized, pleasurable …

Infections are important factors contributing to the morbidity and mortality among elderly
patients. High rates of consumption of antimicrobial agents by the elderly may result in …

Crohn's disease affects the mucosal layer of the intestine, predominantly ileum and colon
segments, with the potential to affect the expression of intestinal enzymes and transporters …

Healthcare is increasingly fragmented, resulting in escalating costs, patient dissatisfaction,
and sometimes adverse clinical outcomes. Strategies to decrease healthcare fragmentation …

Bacterial vaginosis (BV), primarily attributed to Gardnerella vaginalis, poses significant
challenges due to antibiotic resistance and suboptimal treatment outcomes. This study …

Contending with variability in drug exposure and effect in disease populations requires
patient characterization for changes in drug metabolism and transport pathways and …

Abstract The Simcyp Simulator is a software platform widely used in the pharmaceutical
industry to conduct stochastic physiologically‐based pharmacokinetic (PBPK) modeling …

In vitro–in vivo extrapolation (IVIVE) allows prediction of clinical outcomes across
populations from in vitro data using specific scalars tailored to the biologic characteristics of …

Physiologically based pharmacokinetic (PBPK) modeling is a physiologically relevant
approach that integrates drug-specific and system parameters to generate pharmacokinetic …

The most common method for establishing bioequivalence (BE) is to demonstrate similarity
of concentration–time profiles in the systemic circulation, as a surrogate to the site of action …