It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even
in the presence of oxygen, and glycolysis is a known modulator of tumorigenesis and tumor …

Adoptive cell therapy using chimeric antigen receptor (CAR) technology is one of the most
advanced engineering platforms for cancer immunotherapy. CAR-T cells have shown …

The complexity and plasticity of the tumor microenvironment (TME) make it difficult to fully
understand the intratumoral regulation of different cell types and their activities …

Macrophages are specialized immune cells, which have the capacity to phagocytize and
destroy the target cells, including tumor cells. Some macrophages, however on their way to …

The pivotal role of the tumor microenvironment (TME) in the initiation and advancement of
hepatocellular carcinoma (HCC) is widely acknowledged, as it fosters the proliferation and …

Osteosarcoma (OS), the most common malignant tumor in the musculoskeletal system,
mainly occurs in adolescents. OS results in high mortality and disability rates due to a fatal …

Cancer progression and metastasis due to tumor immune evasion and drug resistance is
strongly associated with immune suppressive cellular responses, particularly in the case of …

Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME),
influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit …

Although immune-based therapies have revolutionized the management of cancer, novel
approaches are urgently needed to improve their outcome. We investigated the role of …

Simple Summary The highly metastatic and immunosuppressive microenvironment of
ovarian cancers is a major determinant of the aggressive nature and therapeutic resistance …