Drugging the efferocytosis process: concepts and opportunities

P Mehrotra, KS Ravichandran - Nature reviews Drug discovery, 2022 - nature.com
The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …

Efferocytosis and its role in inflammatory disorders

Y Ge, M Huang, Y Yao - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Efferocytosis is the effective clearance of apoptotic cells by professional and non-
professional phagocytes. The process is mechanically different from other forms of …

[HTML][HTML] The efferocytosis process in aging: Supporting evidence, mechanisms, and therapeutic prospects for age-related diseases

M Zhang, J Wei, Y Sun, C He, S Ma, X Pan… - Journal of Advanced …, 2024 - Elsevier
Background Aging is characterized by an ongoing struggle between the buildup of damage
caused by a combination of external and internal factors. Aging has different effects on …

Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host

K Zhang, U Repnik, N Diab, D Friske, A Pütz… - Journal of Experimental …, 2024 - rupress.org
The intestinal epithelium is the first line of defense against enteric pathogens. Removal of
infected cells by exfoliation prevents mucosal translocation and systemic infection in the …

From cytokine storm to cytokine breeze: did lessons learned from immunopathogenesis improve immunomodulatory treatment of moderate-to-severe COVID-19?

G Rondovic, D Djordjevic, I Udovicic, I Stanojevic… - Biomedicines, 2022 - mdpi.com
Complex immune response to infection has been highlighted, more than ever, during the
COVID-19 pandemic. This review explores the immunomodulatory treatment of moderate-to …

Efferocytosis and respiratory disease

W Zheng, Z Zhou, X Guo, X Zuo, J Zhang, Y An… - International Journal of …, 2023 - mdpi.com
Cells are the smallest units that make up living organisms, which constantly undergo the
processes of proliferation, differentiation, senescence and death. Dead cells need to be …

Efferocytosis: a double-edged sword in microbial immunity

F Mohammad-Rafiei, F Moadab, A Mahmoudi… - Archives of …, 2023 - Springer
Efferocytosis is characterized as the rapid and efficient process by which dying or dead cells
are removed. This type of clearance is initiated via" find-me" signals, and then, carries on by" …

Efferocytosis in lung mucosae: implications for health and disease

K Guimarães-Pinto, EP Maia, JRM Ferreira… - Immunology Letters, 2022 - Elsevier
Efferocytosis is imperative to maintain lung homeostasis and control inflammation.
Populations of lung macrophages are the main efferocytes in this tissue, responsible for …

Oral infections, SARS-CoV-2 infection, and autoimmunity

SJ Janket, F Tamimi, JH Meurman - Infection and autoimmunity, 2024 - Elsevier
A new strain of virus, SARS-CoV-2, caused the coronavirus disease of 2019 (COVID-19)
and became the greatest global health challenge. Even though most patients (over 80% of …

Overnutrition and Lipotoxicity: Impaired Efferocytosis and Chronic Inflammation as Precursors to Multifaceted Disease Pathogenesis

V Mann, A Sundaresan, S Shishodia - Biology, 2024 - mdpi.com
Simple Summary Overnutrition, characterized by an excessive caloric intake, often leads to
lipotoxicity, a condition where lipids accumulate abnormally in non-adipose tissues. This …