The emerging roles of HDACs and their therapeutic implications in cancer

R Hai, D Yang, F Zheng, W Wang, X Han… - European Journal of …, 2022 - Elsevier
Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

[HTML][HTML] RNA-based therapies: a cog in the wheel of lung cancer defense

P Khan, JA Siddiqui, I Lakshmanan, AK Ganti, R Salgia… - Molecular cancer, 2021 - Springer
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …

[HTML][HTML] Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p

J Lou, J Wu, M Feng, X Dang, G Wu, H Yang… - Journal of Sport and …, 2022 - Elsevier
Background Angiogenesis constitutes a major mechanism responsible for exercise-induced
beneficial effects. Our previous study identified a cluster of differentially expressed …

[HTML][HTML] Focus: the science of stress: oxidative stress and inflammation in cardiovascular diseases and cancer: role of non-coding RNAs

P Ginckels, P Holvoet - The Yale Journal of Biology and Medicine, 2022 - ncbi.nlm.nih.gov
Abstract High oxidative stress, Th1/Th17 immune response, M1 macrophage inflammation,
and cell death are associated with cardiovascular diseases. Controlled oxidative stress …

Differential molecular mechanistic behavior of HDACs in cancer progression

T Singh, P Kaur, P Singh, S Singh, A Munshi - Medical Oncology, 2022 - Springer
Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms
normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors …

[HTML][HTML] A review on the role of oncogenic lncRNA OIP5-AS1 in human malignancies

S Ghafouri-Fard, S Dashti, M Farsi, BM Hussen… - Biomedicine & …, 2021 - Elsevier
OIP5-AS1 is a long non-coding transcript with high expression in nervous system, but crucial
functions in the neoplastic transformation. This lncRNA partake in the regulation of cell cycle …

The role of lncRNA OIP5-AS1 in cancer development and progression

C Zheng, M Chu, Q Chen, C Chen, ZW Wang, X Chen - Apoptosis, 2022 - Springer
Abstract OIP5-AS1, a conserved lncRNA, has been reported to be involved in several
biological and pathological processes, including oncogenesis. OIP5-AS1 exerts its …

[HTML][HTML] An in-silico approach leads to explore six genes as a molecular signatures of lung adenocarcinoma

MA Abdel-Maksoud, F Hassan, U Mubarik… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Due to heterogenetic-specific nature of the available biomarkers, the incidence of lung
adenocarcinoma (LUAD) is on the rise worldwide. Previously reported LUAD-related hub …

Long non‐coding RNA OIP5‐AS1 (Cyrano): A context‐specific regulator of normal and disease processes

S Wooten, KN Smith - Clinical and Translational Medicine, 2022 - Wiley Online Library
Long non‐coding (lnc) RNAs have been implicated in a plethora of normal biological
functions, and have also emerged as key molecules in various disease processes. OIP5 …

Down‐regulation of OIP5‐AS1 inhibits obesity‐induced myocardial pyroptosis and miR‐22/NLRP3 inflammasome axis

Q Yue, Y Liu, J Ji, T Hu, T Lin, S Yu… - Immunity, Inflammation …, 2023 - Wiley Online Library
Background Obesity can induce myocardial pyroptosis, but the exact mechanism is still
unknown. A recent study reported the association of opa‐interacting protein 5‐antisense …