One of the features of malignant gliomas is their deviant resistance to cellular apoptosis
induced by cytotoxic reagents. Bmi-1, an oncoprotein, has been linked to oncogenesis and …

Background The BMI1 oncogene is overexpressed in several human malignancies
including gastric cancer. In addition to BMI1, mammalian cells also express Mel-18, which is …

Background BMI-1 is a member of the polycomb group of genes (PcGs), and it has been
implicated in the development and progression of several malignancies, but its role in …

Polycomb group (PcG) proteins are overexpressed in several human malignancies
including breast cancer. In particular, aberrant expression of BMI1 and EZH2 has been …

Abstract Background Chromobox 7 (CBX7) is a Polycomb family protein that extends the
lifespan of normal human cells via downregulating the expression of INK4a/ARF tumor …

BMI1 oncogene is a catalytic member of epigenetic repressor polycomb group proteins. It
plays a critical role in the regulation of gene expression pattern and consequently several …

Bmi-1 is a member of the Polycomb group family of proteins that function in the epigenetic
silencing of genes governing self-renewal, differentiation, and proliferation. Bmi-1 was first …

The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential
for organ growth and tumorigenesis. Recently, we reported that the ubiquitin E3 ligase ITCH …

Bmi1 is a polycomb group proto-oncogene that has been implicated in multiple tumor types.
However, its role in hepatocellular carcinoma (HCC) development has not been well …

Hinokitiol (β-thujaplicin) is a tropolone-related compound that has anti-microbe, anti-
inflammation, and anti-tumor effects. Cancer stem/progenitor cells (CSCs) are a …