DDB2 is a sensor of DNA damage and it plays an important role in Global Genomic Repair
(GG-NER). Our previous studies show that DDB2 is involved in the regulation of metastasis …

The polycomb group family protein BMI-1 is overexpressed by and functions as an
oncogene in many different human cancers. We have previously shown that BMI-1 promotes …

Responses of GH-secreting adenomas to multimodal management of acromegaly vary
widely between patients. Understanding the behavioral patterns of GH-secreting adenomas …

Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide.
Although the risk factors of human HCC are well known, the molecular pathogenesis of this …

Most breast cancers occur sporadically due to long-term exposure to low-dose carcinogens
in the diet and the environment. Specifically, smoke, polluted air, and high-temperature …

Bmi-1, a member of the polycomb family, it is involved in self renewal of stem cells and
functions as an oncogene in many malignant human cancer types. Recent studies have …

The polycomb group protein BMI1 is an important regulator of cancer stem cell (CSC)
phenotype and is often overexpressed in cancer cells. Its overexpression leads to increase …

Endothelial cells (ECs) possess a strong intrinsic clockwise (CW, or rightward) chirality
under normal conditions. Enervating this chirality of ECs significantly impairs the function of …

Breast cancer is the most common type of cancer affecting women in North America and
Europe. More than 85% of breast cancers are sporadic and attributable to long-term …

Abstract Background The Polycomb group (PcG) genes are a class of regulators responsible
for maintaining homeotic gene expression throughout cell division. PcG expression is …