Optimization of spray drying process parameters for the food bioactive ingredients

M Homayoonfal, N Malekjani, V Baeghbali… - Critical Reviews in …, 2022 - Taylor & Francis
Spray drying (SD) is one of the most important thermal processes used to produce different
powders and encapsulated materials. During this process, quality degradation might …

Advances in numerical simulation of unit operations for tablet preparation

Z Li, WH Peng, WJ Liu, LY Yang, A Naeem… - International Journal of …, 2023 - Elsevier
Recently, there has been an increase in the use of numerical simulation technology in
pharmaceutical preparation processes. Numerical simulation can contribute to a better …

Enhancing efficiency in particle aggregation simulations: Coarse-grained particle modeling in the DEM-PBM coupled framework

T De, A Das, M Singh, J Kumar - Computer Methods in Applied Mechanics …, 2023 - Elsevier
The computational cost of the discrete element method (DEM)-population balance model
(PBM) coupled framework is predominantly attributed to DEM simulations. To overcome this …

Challenges in the simulation of drying in fluid bed granulation

M Askarishahi, MS Salehi, S Radl - Processes, 2023 - mdpi.com
Fluid bed granulation is faced with a high level of complexity due to the simultaneous
occurrence of agglomeration, breakage, and drying. These complexities should be …

Investigating chemical heterogeneity in inclusion populations: A multivariate population balance model study in gas-stirred ladles

A Das, JS Kroll-Rabotin, T Quatravaux… - Industrial & …, 2023 - ACS Publications
Achieving high mechanical performance in metallic materials requires precise control of the
inclusion population, and the treatment of liquid steel in gas-stirred ladles is crucial for …

New discrete formulation for reduced population balance equation: an illustration to crystallization

M Singh, G Walker - Pharmaceutical Research, 2022 - Springer
In this paper, we focus on providing a discrete formulation for a reduced aggregation
population balance equation. The new formulation is simpler, easier to code, and adaptable …

An efficient multiscale bi-directional PBM-DEM coupling framework to simulate one-dimensional aggregation mechanisms

A Das, T De, G Kaur, M Dosta… - Proceedings of the …, 2022 - royalsocietypublishing.org
The mesoscale population balance modelling (PBM) technique is widely used in predicting
aggregation processes. The accuracy and efficiency of PBM depend on the formulation of its …

On the prediction of particle collision behavior in coarse-grained and resolved systems

T De, A Das, J Kumar - Particulate Science and Technology, 2023 - Taylor & Francis
The discrete element method (DEM) simulates granular processes and detects inter-particle
collisions during the simulation. Detection of collision helps researchers to study the …

Monte Carlo modeling of spray agglomeration in a cylindrical fluidized bed: From batch-wise to continuous processes

J Du, G Strenzke, A Bück, E Tsotsas - Powder Technology, 2022 - Elsevier
Monte Carlo method is a stochastic approach that can simulate different micro-mechanisms
occurring in spray fluidized bed (SFB) agglomeration. As no model covered the simulation of …

Mathematical modeling of different breakage PBE kernels using Monte Carlo simulation results

A Das, J Kumar - Optimization of Pharmaceutical Processes, 2021 - Springer
This chapter discusses the development of some breakage PBE kernels. Three different
types of breakage processes are considered, namely linear breakage, nonlinear collisional …