Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an
immunopathogenesis that is particularly well understood. The condition is characterized by …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

Colonic antigen-experienced lymphocytes such as tissue-resident memory CD8+ T cells can
respond rapidly to repeated antigen exposure. However, their cellular phenotypes and the …

Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Consumption of probiotics as a useful functional food improves the host's wellbeing, and,
when paired with prebiotics (indigestible dietary fibre/carbohydrate), often benefits the host …

Emigration of tissue-resident memory T cells (TRMs) was recently introduced in mouse
models and may drive systemic inflammation. Skin TRMs of patients undergoing allogeneic …