Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …

Nsp15 is a uridine specific endoribonuclease that coronaviruses employ to cleave viral RNA
and evade host immune defense systems. Previous structures of Nsp15 from across …

COVID-19 is the most consequential pandemic of the 21st century. Since the earliest stage
of the 2019-2020 epidemic, animal models have been useful in understanding the …

The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge …

Some of the most efficacious antiviral therapeutics are ribonucleos (t) ide analogs. The
presence of a 3′-to-5′ proofreading exoribonuclease (ExoN) in coronaviruses diminishes …

Fluorescence facilitates the detection, visualization, and tracking of molecules with high
sensitivity and specificity. A functional DNA molecule that generates a robust fluorescent …

Abstract SARS‐CoV‐2 (SCoV2) and its variants of concern pose serious challenges to the
public health. The variants increased challenges to vaccines, thus necessitating for …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses mRNA capping to
evade the human immune system. The cap formation is performed by the SARS-CoV-2 …