Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

S Basu, T Mak, R Ulferts, M Wu, T Deegan… - Biochemical …, 2021 - portlandpress.com
The COVID-19 pandemic has presented itself as one of the most critical public health
challenges of the century, with SARS-CoV-2 being the third member of the Coronaviridae …

[PDF][PDF] Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser

RJ Jernigan, D Logeswaran, D Doppler, N Nagaratnam… - Structure, 2023 - cell.com
NendoU from SARS-CoV-2 is responsible for the virus's ability to evade the innate immune
system by cleaving the polyuridine leader sequence of antisense viral RNA. Here we report …

Pharmaceutical prospects of curcuminoids for the remedy of COVID-19: Truth or myth

YS Fu, WY Ho, N Kang, MJ Tsai, J Wu… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), which is a positive-strand RNA virus, and has rapidly spread …

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

AP Bertolin, F Weissmann, J Zeng, V Posse… - Biochemical …, 2021 - portlandpress.com
The coronavirus disease 2019 (COVID-19) global pandemic has turned into the largest
public health and economic crisis in recent history impacting virtually all sectors of society …

Opportunities and challenges in targeting the proofreading activity of SARS-CoV-2 polymerase complex

J Deval, ZA Gurard-Levin - Molecules, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic. While the development of vaccines and the emergence of antiviral …

Kinetic analysis of RNA cleavage by coronavirus Nsp15 endonuclease: Evidence for acid–base catalysis and substrate-dependent metal ion activation

T Huang, KC Snell, N Kalia, S Gardezi, L Guo… - Journal of Biological …, 2023 - ASBMB
Understanding the functional properties of severe acute respiratory syndrome coronavirus 2
nonstructural proteins is essential for defining their roles in the viral life cycle, developing …

Novel ciprofloxacin and norfloxacin-tetrazole hybrids as potential antibacterial and antiviral agents: Targeting S. aureus topoisomerase and SARS-CoV-2-MPro

J Cardoso-Ortiz, S Leyva-Ramos, KM Baines… - Journal of Molecular …, 2023 - Elsevier
This study was designed to synthesize hybridizing molecules from ciprofloxacin and
norfloxacin by enhancing their biological activity with tetrazoles. The synthesized …

In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity

TSH Mohammad, Y Gupta, CT Reidl… - International journal of …, 2023 - mdpi.com
The landscape of viral strains and lineages of SARS-CoV-2 keeps changing and is currently
dominated by Delta and Omicron variants. Members of the latest Omicron variants, including …

Development of Pan-Anti-SARS-CoV-2 Agents through Allosteric Inhibition of nsp14/nsp10 Complex

J Chen, Y Zhou, X Wei, X Xu, Z Qin, CP Ong… - ACS Infectious …, 2023 - ACS Publications
SARS-CoV-2 nsp14 functions both as an exoribonuclease (ExoN) together with its critical
cofactor nsp10 and as an S-adenosyl methionine-dependent (guanine-N7) …

Recent insights into the structure and function of coronavirus ribonucleases

MN Frazier, AA Riccio, IM Wilson… - FEBS Open …, 2022 - Wiley Online Library
Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode
nonstructural proteins (nsps) with diverse functions that assist in viral replication and …