Structural biology of SARS-CoV-2 endoribonuclease NendoU (nsp15)
The SARS-CoV-2's endoribonuclease (NendoU) nsp15, is an Mn2+ dependent
endoribonuclease specific to uridylate that SARS-CoV-2 uses to avoid the innate immune …
endoribonuclease specific to uridylate that SARS-CoV-2 uses to avoid the innate immune …
Developing new tools to fight human pathogens: A journey through the advances in RNA technologies
VG Costa, SM Costa, M Saramago, MV Cunha… - Microorganisms, 2022 - mdpi.com
A long scientific journey has led to prominent technological advances in the RNA field, and
several new types of molecules have been discovered, from non-coding RNAs (ncRNAs) to …
several new types of molecules have been discovered, from non-coding RNAs (ncRNAs) to …
Mechanistic Basis of Ribonucleotide Incorporation by the SARS-CoV-2 Replication Complex: Fidelity, Inhibition and Drug Design
X Yin - 2023 - search.proquest.com
The SARS-CoV-2 coronavirus has caused a global pandemic. Despite the initial success of
vaccines at preventing infection, genomic variation has led to the proliferation of variants …
vaccines at preventing infection, genomic variation has led to the proliferation of variants …
Target-directed dynamic combinatorial chemistry affords inhibitors of Nsp10 as potential antivirals against SARS-CoV-2
RP Jumde, G Jézéquel, M Saramago, N Frank, S Adam… - 2023 - chemrxiv.org
The development of antiviral drugs against the Severe Acute Respiratory Syndrome
coronavirus 2 (SARS-CoV-2) responsible for the recent worldwide Covid-19 pandemic is …
coronavirus 2 (SARS-CoV-2) responsible for the recent worldwide Covid-19 pandemic is …
Genomic, proteomic and metabolomic profiling of severe acute respiratory syndrome-Coronavirus-2
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome-Coronavirus-2 (SARS-CoV-2) is one of the worst human health problems faced …
syndrome-Coronavirus-2 (SARS-CoV-2) is one of the worst human health problems faced …
[PDF][PDF] Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication
M Koukni, P Arzel, M Zwaagstra, H Lyoo, P Wanningen… - 2022 - discovery.dundee.ac.uk
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, has led to a pandemic, that continues to be a huge public health burden. Despite …
COVID-19, has led to a pandemic, that continues to be a huge public health burden. Despite …
Analyzing Inhibitors of the SARS-CoV-2 Endoribonuclease nsp15
M Staunton - 2022 - digitalcommons.lib.uconn.edu
The global pandemic caused by the virus SARS-CoV-2 has devastated the world. A flurry of
research into the structures and activities of the virus have identified several viable targets …
research into the structures and activities of the virus have identified several viable targets …
Understanding the cleavage characteristics of ribonucleases cusativin and MC1 used in RNA modification mapping
P Thakur - 2021 - search.proquest.com
This dissertation is focused on understanding the cleavage characteristics of two novel
ribonucleases MC1 and cusativin, and their utility in RNA modification mapping …
ribonucleases MC1 and cusativin, and their utility in RNA modification mapping …
Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease
The emergence of severe acute respiratory syndrome coronavirus 2, the causative agent of
coronavirus disease 2019, has resulted in the largest pandemic in recent history. Current …
coronavirus disease 2019, has resulted in the largest pandemic in recent history. Current …