The pharmacokinetics (PK) of SB-240563 have been investigated after iv and sc
administration to cynomolgus monkeys. Approximately linear PK was observed following iv …

Interleukin-5 (IL-5) stimulates proliferation and differentiation of B cells and eosinophils. IL-5
receptor (IL-5R) comprises α and βc chains. IL-5 specifically binds to IL-5Rα and induces the …

Stem cell factor (SCF) has been suggested as essential for optimal production of various
hematopoietic lineages mainly because of its apoptosis prevention function when it …

After a period of resistance, the concept of human helper T (TH)-ceIl subsets is gaining
currency. This is the result of analyses from a number of laboratories on the cytokine profiles …

Cytokines play a significant part in many biological mechanisms including a number of
reproductive processes. The latter number is increasing rapidly as research in this area …

Summary Interleukin (IL)‐5 induces CD38‐activated splenic B cells to differentiate into
immunoglobulin M‐secreting cells and undergo µ to γ1 class switch recombination (CSR) at …

The view of eosinophils (Eos) as solely effector cells involved in host parasite defense and
in the pathophysiology of allergic diseases has been challenged in recent years. In fact …

Substantial evidence indicates a close relationship between eosinophils and basophils. We
examined whether interleukin 5 (IL-5), known to be eosinophilopoietic and capable of …

The study of cytokines started about 40 years ago with Isaacs and Lindemann's discovery
that interferon is an antiviral agent produced by the cells in response to viral attack (1). Over …

Publisher Summary This chapter discusses the interactions between T and B cells and the
role of accessory cells and cytokines in the generation of specific antibody responses. The …