Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines

A Sette, S Crotty - Immunological reviews, 2022 - Wiley Online Library
Immunological memory is the basis of protective immunity provided by vaccines and
previous infections. Immunological memory can develop from multiple branches of the …

Correlates of protection against SARS‐CoV‐2 infection and COVID‐19 disease

D Goldblatt, G Alter, S Crotty… - Immunological reviews, 2022 - Wiley Online Library
Antibodies against epitopes in S1 give the most accurate CoP against infection by the SARS‐
CoV‐2 coronavirus. Measurement of those antibodies by neutralization or binding assays …

T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

[HTML][HTML] Dysregulation of brain and choroid plexus cell types in severe COVID-19

AC Yang, F Kern, PM Losada, MR Agam, CA Maat… - Nature, 2021 - nature.com
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …

T cells in health and disease

L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

[HTML][HTML] Adaptive immunity to SARS-CoV-2 and COVID-19

A Sette, S Crotty - Cell, 2021 - cell.com
The adaptive immune system is important for control of most viral infections. The three
fundamental components of the adaptive immune system are B cells (the source of …

Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

J Mateus, JM Dan, Z Zhang, C Rydyznski Moderbacher… - Science, 2021 - science.org
INTRODUCTION Understanding human immune responses to severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) RNA vaccines is of interest for a panoply of reasons …

The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses

SM Murray, AM Ansari, J Frater, P Klenerman… - Nature Reviews …, 2023 - nature.com
Pre-existing cross-reactive immune responses to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by …

Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases

A Tarke, J Sidney, CK Kidd, JM Dan, SI Ramirez… - Cell Reports …, 2021 - cell.com
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of
immunodominance of different SARS-CoV-2 antigens and precisely measure virus-specific …

scAAGA: Single cell data analysis framework using asymmetric autoencoder with gene attention

R Meng, S Yin, J Sun, H Hu, Q Zhao - Computers in biology and medicine, 2023 - Elsevier
In recent years, single-cell RNA sequencing (scRNA-seq) has emerged as a powerful
technique for investigating cellular heterogeneity and structure. However, analyzing scRNA …