The cGAS–STING pathway and cancer
N Samson, A Ablasser - Nature cancer, 2022 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
The type I interferonopathies: 10 years on
YJ Crow, DB Stetson - Nature Reviews Immunology, 2022 - nature.com
As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …
The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
Immunology of aging: the birth of inflammaging
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
[HTML][HTML] Delivery of STING agonists for adjuvanting subunit vaccines
Adjuvant is an essential component in subunit vaccines. Many agonists of pathogen
recognition receptors have been developed as potent adjuvants to optimize the …
recognition receptors have been developed as potent adjuvants to optimize the …
Endogenous retroelements and the viral mimicry response in cancer therapy and cellular homeostasis
Features of the cancer epigenome distinguish cancers from their respective cell of origin and
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …
Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity
C Zhou, X Chen, R Planells-Cases, J Chu, L Wang… - Immunity, 2020 - cell.com
The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …
Structural mechanism of cGAS inhibition by the nucleosome
GR Pathare, A Decout, S Glück, S Cavadini… - Nature, 2020 - nature.com
The DNA sensor cyclic GMP–AMP synthase (cGAS) initiates innate immune responses
following microbial infection, cellular stress and cancer. Upon activation by double-stranded …
following microbial infection, cellular stress and cancer. Upon activation by double-stranded …
[HTML][HTML] cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
Summary Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for the
immune response to cancer and pathogen infection. Here, we discover that cGAS-DNA …
immune response to cancer and pathogen infection. Here, we discover that cGAS-DNA …