Cellular and molecular heterogeneity associated with vessel formation processes

PR Castro, AS Barbosa, JM Pereira… - BioMed research …, 2018 - Wiley Online Library
The microvasculature heterogeneity is a complex subject in vascular biology. The difficulty of
building a dynamic and interactive view among the microenvironments, the cellular and …

[HTML][HTML] Proteome of the luminal surface of the blood–brain barrier

JJ Hill, AS Haqqani, DB Stanimirovic - Proteomes, 2021 - mdpi.com
Interrogation of the molecular makeup of the blood–brain barrier (BBB) using proteomic
techniques has contributed to the cataloguing and functional understanding of the proteins …

Large-Scale Quantitative Comparison of Plasma Transmembrane Proteins between Two Human Blood–Brain Barrier Model Cell Lines, hCMEC/D3 and HBMEC/ciβ

T Masuda, T Hoshiyama, T Uemura… - Molecular …, 2019 - ACS Publications
Transmembrane (TM) proteins localized at the plasma membrane, such as transporters and
receptors, play important roles in regulating the selective permeability of the blood–brain …

[HTML][HTML] Expression of periaxin (PRX) specifically in the human cerebrovascular system: PDZ domain-mediated strengthening of endothelial barrier function

MM Wang, X Zhang, SJ Lee, S Maripudi, RF Keep… - Scientific reports, 2018 - nature.com
Regulation of cerebral endothelial cell function plays an essential role in changes in blood-
brain barrier permeability. Proteins that are important for establishment of endothelial tight …

Uncovering the potential differentially expressed miRNAs and mRNAs in ischemic stroke based on integrated analysis in the gene expression omnibus database

X Zhu, X Liu, Y Liu, W Chang, Y Song, S Zhu - European neurology, 2020 - karger.com
Introduction: Ischemic stroke is the third leading cause of death. There is no known treatment
or cure for the disease. Moreover, the pathological mechanism of ischemic stroke remains …

[HTML][HTML] Comprehensive analysis of lncRNA-miRNA-mRNA ceRNA network in ischemic stroke

L Cheng, Y Zhao, H Ke - Heliyon, 2024 - cell.com
Abstract Objective Competitive endogenous RNA (ceRNA) networks have uncovered a
novel mode of RNA interaction, and are implicated in various biological processes and the …

[HTML][HTML] The year in review: progress in brain barriers and brain fluid research in 2018

RF Keep, HC Jones, LR Drewes - Fluids and Barriers of the CNS, 2019 - Springer
This editorial focuses on the progress made in brain barrier and brain fluid research in 2018.
It highlights some recent advances in knowledge and techniques, as well as prevalent …

[HTML][HTML] Tripartite factors leading to molecular divergence between human and murine smooth muscle

SJ Lee, S Blanchett-Anderson, SG Keep, MB Gasche… - PloS one, 2020 - journals.plos.org
A large number of pre-clinical and developmental investigations involve experimental
vertebrate animals, of which mice have emerged as a favored organism. Recognition of the …

[HTML][HTML] Concentration of non-myocyte proteins in arterial media of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

SJ Lee, A Kondepudi, KZ Young, X Zhang… - Plos one, 2023 - journals.plos.org
The most common inherited cause of vascular dementia and stroke, cerebral autosomal
dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is …

[HTML][HTML] Context-dependent monoclonal antibodies against protein carbamidomethyl-cysteine

NMP Cartee, SJ Lee, SG Keep, MM Wang - Plos one, 2020 - journals.plos.org
Protein sulfhydryl residues participate in key structural and biochemical functions.
Alterations in sulfhydryl status, regulated by either reversible redox reactions or by …