Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton‐Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment

E Kirbas Cilingir, O Besbinar, L Giro, M Bartoli… - Small, 2024 - Wiley Online Library
The appeal of carbon dots (CDs) has grown recently, due to their established
biocompatibility, adjustable photoluminescence properties, and excellent water solubility …

The mechanism of ferroptosis and its related diseases

S Feng, D Tang, Y Wang, X Li, H Bao, C Tang… - Molecular …, 2023 - Springer
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated
accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of …

Copper induces neuron‐sparing, ferredoxin 1‐independent astrocyte toxicity mediated by oxidative stress

JR Gale, K Hartnett‐Scott, MM Ross… - Journal of …, 2023 - Wiley Online Library
Copper is an essential enzyme cofactor in oxidative metabolism, anti‐oxidant defenses, and
neurotransmitter synthesis. However, intracellular copper, when improperly buffered, can …

New insights into regulatory cell death and acute pancreatitis

H Li, D Wu, H Zhang, P Li - Heliyon, 2023 - cell.com
Acute pancreatitis (AP) may be associated with both local and systemic complications.
Although it is usually self-limiting, up to 20% of patients develop severe acute pancreatitis …

Nanoenabled intracellular metal ion homeostasis regulation for tumor therapy

L Xu, M Peng, T Gao, D Wang, X Lian, H Sun… - Advanced …, 2024 - Wiley Online Library
Endogenous essential metal ions play an important role in many life processes, especially in
tumor development and immune response. The approval of various metallodrugs for tumor …

Copper metabolism and cuproptosis in human malignancies: Unraveling the complex interplay for therapeutic insights

KM Abdullah, JB Kaushal, S Takkar, G Sharma… - Heliyon, 2024 - cell.com
Copper, a vital trace element, orchestrates diverse cellular processes ranging from energy
production to antioxidant defense and angiogenesis. Copper metabolism and cuproptosis …

Biomimetic nano-chelate diethyldithiocarbamate Cu/Fe for enhanced metalloimmunity and ferroptosis activation in glioma therapy

R Wang, W Song, J Zhu, X Shao, C Yang… - Journal of Controlled …, 2024 - Elsevier
Ferroptosis has emerged as a promising therapeutic approach for glioma. However, its
efficacy is often compromised by the activated GPX4-reduced glutathione (GSH) system and …

Co-exposure to Fe, Zn, and Cu induced neuronal ferroptosis with associated lipid metabolism disorder via the ERK/cPLA2/AA pathway

W Shi, H Zhang, Y Zhang, L Lu, Q Zhou, Y Wang… - Environmental …, 2023 - Elsevier
Excessive amounts of iron (Fe), zinc (Zn), and copper (Cu) can be toxic to neuronal cells,
even though these are essential trace elements for animals and humans. However, the …

[HTML][HTML] Deciphering the link: ferroptosis and its role in glioma

H Wang, Y Liu, S Che, X Li, D Tang, S Lv… - Frontiers in …, 2024 - frontiersin.org
Glioma, as the most frequently occurring primary malignancy in the central nervous system,
significantly impacts patients' quality of life and cognitive abilities. Ferroptosis, a newly …

Copper exposure induced chicken hepatotoxicity: involvement of ferroptosis mediated by lipid peroxidation, ferritinophagy, and inhibition of FSP1-CoQ10 and nrf2 …

G Zhong, Y Li, F Ma, Y Huo, J Liao, Q Han, L Hu… - … Trace Element Research, 2024 - Springer
Copper (Cu) is one of the most significant trace elements in the body, but it is also a
widespread environmental toxicant health. Ferroptosis is a newly identified programmed cell …