Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Inflammation promotes the development of heart failure (HF). The inflammasome is a
multimeric protein complex that plays an essential role in the innate immune response by …

Abstract NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome
pathway has a critical role in the pathogenesis of atherosclerosis. Activation of this pathway …

More than 80 million people live and work (in a chronic or intermittent form) above 2500
masl, and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that …

Primary percutaneous coronary intervention (PPCI) is the gold standard of treatment in
patients with acute ST-elevation myocardial infarction (STEMI). The no-reflow phenomenon …

Background and aim Heart failure (HF) is a complex clinical syndrome that represents the
end result of several pathophysiologic processes. Despite a dramatic evolution in diagnosis …

Obesity is often accompanied by hypertension. Although a large number of studies have
confirmed that NLRP3 inhibitors can improve cardiac remodeling in mice with a normal diet …

Purpose: Hydrogen (H 2) is an antioxidant with anti-inflammatory and apoptosis functions.
This study aimed to estimate the effects of H 2 on acute myocardial infarction (AMI) in rats …

Over the last decades, inflammation proved to play a pivotal role in atherosclerotic plaque
formation, progression and destabilization. Several studies showed that the patients …

Activation of the NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway is
an important mechanism underlying myocardial pyroptosis and plays an important role in …